General Information

  • ID:  hor000505
  • Uniprot ID:  B7PFR9
  • Protein name:  Myoinhibitory peptide
  • Gene name:  MIP
  • Organism:  Ixodes scapularis (Black-legged tick) (Deer tick)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ixodes (genus), Ixodinae (subfamily), Ixodidae (family), Ixodoidea (superfamily), Ixodida (order), Parasitiformes (superorder), Acari (subclass), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ASDWNRLSGMW
  • Length:  11(71-81)
  • Propeptide:  MSPVESSRHAGRRPVVATYGESGRTATSAVVLSRSLLVLLVLAALLCCSAAEPQPQGGDWNALSGMWGKRASDWNRLSGMWGKRAGAYGPYQALLLRAEESNDGAGHGISARAAPPGSPRENHWNDLSGYWG
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-B7PFR9-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000505_AF2.pdbhor000505_ESM.pdb

Physical Information

Mass: 150101 Formula: C58H83N17O17S
Absent amino acids: CEFHIKPQTVY Common amino acids: SW
pI: 6.34 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 4
Hydrophobicity: -70.91 Boman Index: -2240
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 44.55
Instability Index: 2030.91 Extinction Coefficient cystines: 11000
Absorbance 280nm: 1100

Literature

  • PubMed ID:  19540946
  • Title:  The Neuropeptidomics of Ixodes Scapularis Synganglion